I'm finding the show quite amusing. Not the funniest thing I've seen but just enough to lighten the mood on some fairly realistic topics.
Episode 1 seemed mostly about character set up to me. We get introduced to the crew and know Ed and Kelley's background.
Episode 2 spoke to me about reacting to being thrust into a position where one has to take charge. Watching Alara's reaction to the sudden absence of command above herself looked a lot like I did when I was promoted to Sergeant in the Army and suddenly had soldiers I was responsible for.
Episode 3; I know everyone seems to think it was about transgender issues. I think that might have been MacFarlane's intent, but he missed. There wasn't much discussion about the child's personal identity which is what trans issues circle around. Instead, the discussion centered on the 'inherent inferiority of females' and was repeated over and over. For this reason I think the episode was a much better portrayal of toxic masculinity.
Episode 4, maybe the moral of the story is to question what you're told? Still thinking on that one.
Episode 5, be careful who you trust.
Episode 6; wow, the Krill are religious extremists. Still, the moral dilemma about what to do to intervene in the upcoming WMD attack on a Union colony seemed appropriate for current events. What is the limit on our target discrimination in self defense?